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Symbol
Name
ID

Hmox1
heme oxygenase 1
MGI:96163

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes

Bleeding with minor or no trauma

Epistaxis

Gingival bleeding

Gastrointestinal hemorrhage

Hematemesis

Melena

Intracranial hemorrhage

Intraventricular hemorrhage

Joint hemorrhage

Muscle hemorrhage

Oral cavity bleeding

Persistent bleeding after trauma

Bruising susceptibility

Purpura

Petechiae

Spontaneous hematomas

Thromboembolism

Reduced factor VIII activity

Prolonged partial thromboplastin time

Splenic rupture

Disease(s) Associated with HMOX1

factor VIII deficiency

Mouse Phenotypes

increased splenocyte proliferation

enlarged spleen

spleen hyperplasia

extramedullary hematopoiesis

anemia

microcytic anemia

decreased erythrocyte cell number

decreased hematocrit

decreased hemoglobin content

decreased mean corpuscular volume

anisocytosis

increased granulocyte number

abnormal leukocyte cell number

increased B cell number

increased CD4-positive, alpha-beta T cell number

increased CD8-positive, alpha-beta T cell number

decreased macrophage cell number

increased macrophage cell number

abnormal splenic cell ratio

Availability

Mouse Genotype

Hmox1^tm1.2Gkl/Hmox1^tm1.2Gkl

Hmox1^tm1Poss/Hmox1^tm1Poss

Hmox1^tm1.1Gkl/Hmox1^tm1.1Gkl
Lyz2^tm1(cre)Ifo/Lyz2⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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